http://www.novonordisk-jobs.com/feeds/immunology-research-jobs/ Custom RSS Feed for immunology-research-jobs Mon, 06 Sep 2010 19:09:52 GMT en-us /sites/novonordisk/images/Novo_Banner.gif http://www.novonordisk-jobs.com/feeds/immunology-research-jobs/ 720 Title DIRECTOR, CELLULAR IMMUNOLOGY
Job Description Director, Cellular Immunology

? Reports to CVP, NNIRC (Biology US)
? Location : Seattle, Washington
? Role: Build and lead a research group in Cellular Immunology

The Cellular Immunology department will be engaged in identifying, evaluating, and validating potential protein-based lead candidates and protein-drug targets in the area of autoimmune and inflammatory diseases. The incumbent will initiate and direct scientific programs aimed at the discovery of novel drug candidates that have potential to modify immune and inflammatory responses and will be expected to bring specific expertise in cellular immunology to bear on these programs.

Drug candidates emerging from discovery programs will be validated with in-vitro cellular immunology in collaboration with NN in-vivo animal pharmacology groups. Emphasis will be given to immune-regulatory protein classes, including cytokines, chemokines, soluble receptors, as well as agonist and antagonist antibodies to these lead classes. The ideal candidate will possess the following:

? Record of Leadership experience in Autoimmunity/Inflammation Programs/Projects
? Track-record of delivering Autoimmune protein drug candidates to a clinical development pipeline
? Strong experience and background in autoimmune diseases and Inflammation
? Familiarity with animal models of rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and SLE
? Strong cellular immunology training and background
? in-vitro cell biology
? in-vivo modeling

? Industry experience with protein-based biologics

Responsibilities:

? Member of NNIRC management team
? Build biology expertise (T cell, Macrophage/APC, cytokine biology) consistent with corporate strategy
? Provide direction to Inflammation Research projects in US site
? Bring Immunology expertise to shaping research strategy for inflammation
o With External Sourcing, identify and prioritize licensing opportunities and potential alliances
o Building networks with external stakeholders

Candidate Requirements:

? PhD or MD in immunology or related fields
? Scientific excellence in Immunology research demonstrated through scientific publications or patents
? In-depth knowledge of chronic autoimmune/inflammatory diseases
? Leadership record in leading a Research department of at least 10-12
? At least 10 years industrial experience with biologics in core autoimmune diseases
? Track record of tangible delivery of biologic drug candidates from discovery into a development pipeline
? Personal characteristics ? entrepreneurial spirit, cross functional work, personal leadership, drive and energy
Department NNIRC - CELLULAR IMMUNOLOGY
Position Location Seattle, WA
Job/Position State WA
Degree Required Doctorate Degree Required
Percent Travel None]]> Sun, 05 Sep 2010 00:09:00 http://www.novonordisk-jobs.com/job/SEATTLE-DIRECTOR,-CELLULAR-IMMUNOLOGY-Job-WA-98101/698938/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS http://www.novonordisk-jobs.com/job/SEATTLE-DIRECTOR,-CELLULAR-IMMUNOLOGY-Job-WA-98101/698938/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS Title SENIOR RESEARCH ASSOCIATE, MOLECULAR IMMUNOLOGY
Job Description KEY SUCCESS FACTORS: EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
? B.S. with 5+ years or M.S. with 3 years of relevant experience from basic research or the pharmaceutical industry required. Level and title will be commensurate with the experience and education level of the selected candidate.
? Exceptional laboratory skills in molecular cloning, design and construction of expression vectors, and basic knowledge of various recombinant protein expression systems, especially in mammalian cells.
? Expertise in tissue culture, cell transfection, and stable cell line selection.
? Experience in design and utilization of a variety of bioassay platforms.
? Experience in immune cell manipulation, FACS analysis, and ideally cell sorting.
? Hands-on experience in standard protein analysis techniques such as SDS-PAGE, western blots, quantitation assays and immunoprecipitation. Familiarity with proteomic approaches to target discovery preferred.
? Strong analytical and trouble-shooting skills, ability to adjust to changing priorities and to take initiative in generating new approaches and results.
? Demonstration of scientific creativity, independent thought, track record of tangible productivity and consistent contribution to the success of team and company goals.

RELATIONSHIPS:
Reports to a Senior Scientist in Molecular Immunology department at Novo Nordisk Inflammation Research Center (NNIRC). Internal relationships include the project teams and research colleagues internally and globally.

PRINCIPAL ACCOUNTABILITIES:
? Performance of a wide variety of technical procedures and operation of varied lab instrumentation/computer platforms. Able to implement methods using journal articles and/or other scientists as resources, with guidance from supervisor.
? Data Analysis / Interpretation: Able to appropriately analyze and summarize experimental plans and outcomes using various statistical and presentation software tools.
? Trouble Shooting: Able to recognize problems with experiments, suggest causes and propose solutions.
? Knowledge of theoretical basis and objectives of experiments and how they fit into overall project goals. Intellectual investment in assignments through reading related scientific papers and attending relevant scientific presentations.
? Report Preparation & Communication: Ability to prepare clear and accurate protocols, data summaries and quantitative analyses for distribution and/or presentation to project teams, and for inclusion in project reports.
? Knowledge of autoimmune and inflammation highly preferred.
? Excellent written and oral communication skills required.
? Flexibility and the ability to work in a fast-paced, team-oriented environment. Able to independently use appropriate experimental design to carry out an assigned series of experiments to address specific research questions or to implement new methodologies.

Purpose:
The Molecular Immunology Department is engaged in discovering and validating biologics targets for autoimmune and inflammatory diseases. The primary role for this position includes providing technical support and peer leadership to the biopharmaceutical discovery laboratory. Incumbents must be able to design and execute experiments based on an overall description of the data needed to support a hypothesis.
Department NNIRC - MOLECULAR IMMUNOLOGY
Position Location Seattle, WA
Job/Position State WA]]> Sat, 14 Aug 2010 00:08:00 http://www.novonordisk-jobs.com/job/Seattle-SENIOR-RESEARCH-ASSOCIATE,-MOLECULAR-IMMUNOLOGY-Job-WA-98101/878691/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS http://www.novonordisk-jobs.com/job/Seattle-SENIOR-RESEARCH-ASSOCIATE,-MOLECULAR-IMMUNOLOGY-Job-WA-98101/878691/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS Title SENIOR RESEARCH ASSOCIATE, MOLECULAR IMMUNOLOGY
Job Description PURPOSE:

The Molecular Immunology Department is engaged in discovering and validating biologics targets for autoimmune and inflammatory diseases at the molecular level. Primary role for this position includes providing technical support and peer leadership to the biopharmaceutical discovery laboratory. Incumbents have responsibility for research experiments and data integrity, as assigned by management. Incumbents must be able to design and implement an experiment based on an overall description of the intended outcome.

RELATIONSHIPS:

Reports to a Principal Scientist in the Molecular Immunology department at the Novo Nordisk Inflammation Research Center (NNIRC). Internal relationships include the project teams and research colleagues internally and globally.

KEY SUCCESS FACTORS: EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:

? B.S. with 5+ years or M.S. with 3 years of relevant experience from basic research or the pharmaceutical industry required. Level and title will be commensurate with the experience and education level of the selected candidate.
? Exceptional laboratory skills in molecular cloning, design and construction of expression vectors, and basic knowledge of various recombinant protein expression systems especially in mammalian cells.
? Expertise in tissue culture, cell transfection, and stable cell line selection.
? Experience in design and utilization of a variety of bioassay platforms.
? Lab skills in immune cell manipulation, FACS analysis, and ideally cell sorting.
? Experience in expression cloning and expression analysis (e.g. Q-PCR).
? Hands-on experience in standard protein analysis techniques such as SDS-PAGE, Western blots, Quantitation assays, and immunoprecipitation.
? Strong analytical and trouble-shooting skills; ability to adjust to priorities, and to take initiative in generating new approaches and results.
? Demonstration of scientific creativity, independent thought, track record of tangible productivity and consistent contribution to the success of team and company goals.

PRINCIPAL ACCOUNTABILITIES:

? Performance of a wide variety of technical procedures and operation of varied lab instrumentation/computer platforms. Able to implement methods using journal articles and/or other scientists as resources, with guidance from supervisor. Increasing ability to independently design individual experiments.
? Data Analysis / Interpretation: Able to appropriately analyze and summarize experimental plans and outcomes. Evidence of increasing ability to correctly interpret data.
? Trouble Shooting: Able to recognize problems with experiments, suggest causes and propose solutions.
? Knowledge of theoretical basis and objectives of experiments and how they fit into overall project goals. Increasing intellectual involvement in assignments, read related scientific papers, attend relevant scientific presentations.
? Report Preparation & Communication: Ability to prepare clear and accurate protocols, data summaries and quantitative analyses for distribution and/or presentation to project teams, and for inclusion in project reports.
? Knowledge of autoimmune and inflammation highly preferred.
? Excellent written and oral communication skills required.
? Flexibility and the ability to work in a fast-paced, team-Scientific/Technical environment. Able to independently use appropriate experimental design to carry out an assigned series of experiments to address specific research questions or to implement new methodologies.

OTHER:

? Works within Novo Nordisk?s established policies and procedures and ensures alignment of their work to Novo Nordisk fundamentals.
? Ability to work flexible hours and overtime.
? Embraces Novo Nordisk Values in spirit and actions.
Department NNIRC - MOLECULAR IMMUNOLOGY
Position Location Seattle, WA
Job/Position State WA]]> Sat, 14 Aug 2010 00:08:00 http://www.novonordisk-jobs.com/job/Seattle-SENIOR-RESEARCH-ASSOCIATE,-MOLECULAR-IMMUNOLOGY-Job-WA-98101/878692/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS http://www.novonordisk-jobs.com/job/Seattle-SENIOR-RESEARCH-ASSOCIATE,-MOLECULAR-IMMUNOLOGY-Job-WA-98101/878692/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS Title SENIOR RESEARCH SCIENTIST - CELLULAR IMMUNOLOGY
Job Description PURPOSE:

To provide expertise and lead development of research-based competencies in support of multiple biopharmaceutical discovery projects aimed at the identification and early development of novel therapeutics for the control of autoimmune and inflammatory diseases.

RELATIONSHIPS:

Reports to the Department Head. Internal relationships include the project teams, and research colleagues internally and globally. External relationships include relevant parts of the autoimmunity and inflammation research community, including key opinion leaders.

ESSENTIAL FUNCTIONS:

? SCIENTIFIC ROLE
? Day to day supervision of research personnel in a targeted Discovery area.
? Provide unified research-driven innovation and continuous improvement within own Section and across Sections.
? Implement and supervise laboratory studies in support of autoimmunity and inflammation research.
? Work with Department Head to align Department goals with Section focus/goals and ensure that direct reports understand this alignment, as well as their role within the team.
? Assume responsibility for project design and implementation.
? Develop and manage relevant research protocols in support of Discovery efforts.
? Interpret and properly document experimental data.
? Maintain current awareness of scientific literature in targeted Discovery area.
? Provide oversight of patents and patent applications in areas of research relevance.
? Draft scientific reports and prepare presentation slides.
? Organize and prepare manuscripts for publication.
? Attend appropriate external scientific meeting and, where possible, present data.
? Achieve business goals, share information, learnings, knowledge and skills and promote cross-functional teamwork.
? Ensure appropriate level of communication with other Department Heads and with Project Managers.
? Identify potential external collaborators within scientific area and initiate research programs within focus areas.
? Use networking opportunities to provide research opportunities with NNIRC.
? Provide safe and functional research environment.

SCIENTIFIC SUPPORT FOR OTHER COMPANY ACTIVITIES:
? Provide internal education and ongoing scientific support throughout the organization.
? Interact with the biopharmaceutical organization as needed. Insure project visibility and endorsement.

KEY SUCCESS FACTORS: EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS
? Ph.D in the biological sciences followed by a minimum of 8 years of industry or relevant basic research experience in Autoimmunity/Inflammation required or an MS with 12 years of experience required.
? Prior research or related experience in the field (e.g. research in the area of biopharmaceutical discovery and knowledge of the assigned therapeutic area) highly preferred.
? Strong scientific skills required.
? Experience in the supervision and training of technical staff highly preferred.
? Excellent written and oral communication skills required.
? Flexibility and the ability to work in a fast-paced, team-oriented environment are required.
? Excellent interpersonal and motivational skills.

OTHER:
? Works within Novo Nordisk's established policies and procedures and ensures alignment of their work to Novo Nordisk fundamentals.
? Embraces Novo Nordisk Values in spirit and actions.
? Approximately 10% overnight travel required.
Additional Information USE JOB CODE T191C
Department NNIRC - CELLULAR IMMUNOLOGY
Position Location Seattle, WA
Job/Position State WA
Percent Travel 0 - 10%]]> Tue, 17 Aug 2010 00:08:00 http://www.novonordisk-jobs.com/job/Seattle-SENIOR-RESEARCH-SCIENTIST-CELLULAR-IMMUNOLOGY-Job-WA-98101/829487/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS http://www.novonordisk-jobs.com/job/Seattle-SENIOR-RESEARCH-SCIENTIST-CELLULAR-IMMUNOLOGY-Job-WA-98101/829487/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS Title Medical Liaison II ? CO / KS / MO / NE / IA /AR
Job Category Clinical
Job Description To act as a liaison between Novo Nordisk Pharmaceuticals (NNI), the Medical department and key external customers to further scientific exchange, provide product and scientific support and provide information to NNI that improves competitive positioning for current and future products. Utilize own academic credentials and scientific expertise to respond to requests for information from health care providers and organizations.

RELATIONSHIPS:
Reports to the Associate Director / Director, Medical Liaisons. Additional key internal relationships are with other medical staff, e.g., Sr. Director Clinical Affairs, Medical Education Manager, Clinical Research Directors, Clinical Research Associates, Drug Information and Medical Writing and Marketing and Sales personnel. External relationships include: physicians; nurse practitioners; pharmacists, blood bank staff; academic institutions; managed care organizations and HMOs.

ESSENTIAL FUNCTIONS:

FIELD-BASED CLINICAL SUPPORT
?Provide comprehensive support of marketed and development biopharmaceutical products, in particular NovoSeven?, within a specified geographic area of the country.
?Act as a scientific resource for health care providers (HCP?s) and other NNI employees, as required.
?Provide support to HCP?s for publications that relate to current areas of scientific interest.
?Attend assigned medical and scientific meetings to: respond to inquiries from the medical community, address current scientific issues and new data pertaining to NNI products.
?Establish and maintain a functional working relationship with Clinical and Clinical Research Associates working within the Region supporting clinical research directives.

INSURANCE REIMBURSEMENT & COVERAGE PROJECTS
?Develop formulary presentations.
?Design, develop and deliver presentations to individuals and groups of strategic importance to NNI.

COORDINATION OF EDUCATIONAL PROGRAMS
?Support field medical education initiatives in line with the current licensed products and research activities.
?Coordinate customer feedback with respect to sponsored medical education events or needs.
?Assist in training sales representatives on product knowledge and use of technical information in selling situations.

ADVOCACY DEVELOPMENT
?Identify, respond to inquiries and develop relationships with health care providers; identifying those individuals with novel research concepts, clinical experience and expertise, within identified therapeutic areas or the use of NNI products;
?Develop and demonstrate a thorough working knowledge of NNI, its products, current scientific research and publications associated with same.
?Develop and/or maintain a pool of high quality regional participants for advisory meetings.
?Participate in special projects both Regional and National
?In conjunction with Drug Development, contact influential centers and investigators to initiate and/or participate in clinical trials and identify key areas of future research.

ADMINISTRATIVE DUTIES
?Consistently complete administrative duties in an accurate manner and on a timely basis, in line with current SOP?s and working practices.
?Communicate activity through timely submission of reports and highlights.
?Exercise prudent control of field expenses.

KEY SUCCESS FACTORS: EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS

?Advanced degree in pharmacy, medicine/nursing
?Pharm.D., PhD or M.D. degree preferred
?Ph.D. in healthcare related life sciences such as anatomy, physiology, microbiology, immunology
At least two years experience in a health related system, pharmaceutical company, or managed care environment, prior MSL experience preferred

?Direct experience in a clinical area of relevance to the current indications / research preferred.
?Experience in management or implementation of projects related to formulary development, insurance coverage policy guidelines, and/or pharmaco-economics desirable.
?Verbal/written communications - must be able to write and review scientific data.
*Experience requirements may be supplemented by direct, relevant therapeutic area expertise/education as determined by Senior Director, Clinical Affairs.

OTHER:
?Works within Novo Nordisk?s established policies and procedures and ensures alignment of their work to Novo Nordisk fundamentals.
?Embraces Novo Nordisk Values in spirit and actions.
?Approximately 60-70% overnight travel
Department CMR - MEDICAL LIAISONS WEST
Position Location Field Based - Across US
Job/Position State CO
Degree Required Doctorate Degree Required
Percent Travel 60 - 70%]]> Sun, 05 Sep 2010 00:09:00 http://www.novonordisk-jobs.com/job/Princeton-Medical-Liaison-II-?-CO-KS-MO-NE-IA-AR-Job-CO/823275/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS http://www.novonordisk-jobs.com/job/Princeton-Medical-Liaison-II-?-CO-KS-MO-NE-IA-AR-Job-CO/823275/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS Title Director, Clinical Research-Inflammation
Job Description Develop, implement and monitor Clinical Development Strategy and Clinical Development Plan (CDP) for a drug candidate and then help author and implement clinical studies (registrational Phase II and III trials) in therapies for chronic immune-mediated inflammatory diseases, working in a team setting, where effective interaction with highly skilled colleagues, and with internal and external stakeholders, is critical. Provide medical expertise in the therapeutic area with focus on a specific project and be the internal and external spokesperson for medical aspects of a given therapeutic area Provide medical and scientific support in other aspects of company activities in the assigned therapeutic area.

Member of Global Development Inflammation, the first headquarters' program to be sited in US, in Princeton. Reports directly to the Vice President, Medical & Science- Inflammation in NJ. Internal relationships also include working closely with Headquarters, Clinical Trial Operations, Outcomes Research, Statistics, Regulatory Affairs and Marketing and Sales organizations. External relationships will evolve with the drug candidate's development and will include expert advisory board members, investigators, other consultants, and key customer groups.

CLINICAL STUDY MANAGEMENT
?As chairman of the Medical & Science team, establish the Clinical Development Strategy and CDP of a drug candidate.
?Assume the overall medical responsibility during the execution of the Phase II and III studies described in the CDP
?Provide medical input, and act as the medical expert in the global project team, acting as the driving factor in the cross-organisational implementation of clinical strategies.
?Establish and maintain an external support network including investigators, key opinion leaders, and outstanding research scientists
?Establish relevant external advisory boards, in cooperation with relevant stakeholders
?Develop trial outlines and support the development of complete protocols. Cooperate in the development of other necessary documents, for clinical studies, e.g. IMPDs, CTAs, providing expert medical input throughout.
?Assist in identification and recruitment of investigators for clinical studies.
?Assure timely initiation of studies.
?Act as liaison with Regulatory, project teams, and investigators.
?Manage development of medical aspects of all protocol amendments/ deviations.
?Maintain close collaboration with Clinical Operations personnel involved in studies. Actively monitor clinical studies, providing full and timely support for all medical issues raised in the day-to-day activities of protocols, taking the lead in dealing with all medically related issues, especially adversities.
?Provide high-quality input at meetings and interactions with health authorities and in response to questions posed by health authorities worldwide.
?Generate high-level clinical documents for submission of new drug applications worldwide and experts' reports. Support post-submission activities to achieve regulatory approval and optimal labelling to allow successful launch of the drug
?Provide treatment algorithms if applicable
?Participate in Project core group and/or Global Project Team (GPT)
?Be a member of an asset project team, when appropriate
?Participate in relevant safety committees
?Perform Clinical Lab surveillance and all medical consistency checks
?Provide timely and authoritative medical support to Clinical Research, and cooperate fully with Clinical Research, to ensure appropriate trial execution, evaluation, and reporting

PROJECT MANAGEMENT
?Chair the cross-functional Medical- Scientific team of internal and, if required, external researchers involved in the different phases of drug development
?Through the project development team, assure timely initiation and completion of studies of qualified patients.
?Assist in developing clinical program time lines, budgets, and strategies.
?Provide medical input to, and assist in the updating of, Investigator's Brochure, PBPs and CDPs
?Ensure needed medical content of the individual study reports and publications
?Generate ?story-line? for the clinical part of the submission dossier
?Generate high-level clinical documents for submission of new drug applications worldwide and Experts reports
?Present aspects of the Clinical Development Program of a given project at in- and external meetings
?Provide scientific support to NN Congresses, exhibitions and symposia

REGULATORY
?Write and/or review clinical sections of clinical/statistical reports, including investigator's brochures, INDs Pediatric Investigative Plans and NDA.
?Provide medical input to the design, updating and implementation of NDA database structures.
?Assume overall medical responsibility for the content and quality of the Clinical Part of the Submission Dossier
?Provide medical content of the individual study reports and publications based on results from the clinical development program
?Present medical aspects of the clinical development program at internal and external meetings (including regulatory agencies, congresses, investigator meetings etc.)
?Assist in providing medical representation at Regulatory meetings.
?Assist in the interpretation of regulatory guidelines and directives to judge risk and causality

MEDICAL AND SCIENTIFIC SUPPORT FOR OTHER COMPANY ACTIVITIES:
?Medical liaison with the Marketing/Business Developments. Support ongoing sales and marketing objectives by making presentations, as appropriate, to external groups, e.g. academic and community medical departments (grand rounds), professional associations, and P&T committees.
?Review medical content of company education of sales staff and promotional materials and be part of their educational program.
?Oversee company interactions with the expert community.
?Stay abreast of regulatory requirements and guidelines and current trends and medical practice in the fields of immunology, gastroenterology, and rheumatology, including reports and intelligence on key and critical new technologies or treatment advances.
?Represent NN medical department in regulatory interactions, investigators' and expert advisory board meetings, external professional societies, seminars, and conventions
?Must maintain necessary credentials and remain in good standing with the medical community and medical ethics boards.

EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
?M.D. or D.O. required
?4-6 years pharmaceutical experience preferred, especially with strategy and planning of trials involving monoclonal antibodies or other large proteins.
?Prior clinical research or related experience, e.g. monitoring the conduct of clinical studies and knowledge of Phases I through III.
?Documented clinical expertise in the field of auto-immunity is a definite advantage, especially in inflammatory bowel disease. Prior experience in SLE or rheumatoid arthritis is also very relevant.
?Documented ability to thrive within a matrixed organization
?Ability and willingness to quickly adjust to new situations in a continuously developing environment, in an international organization
?Good teamwork skills; the ability to accept coaching a must
?Fluent in written and spoken English with excellent communication skills.
?Proven presentation skills, with oral and written communication expertise
?High energy, excellent coordination and planning skills, considerable flexibility and a keen sense of quality and purpose.
Department CMR - GD INFLAMMATION (1)
Position Location Princeton, NJ
Job/Position State NJ
Degree Required Doctorate Degree Required
Percent Travel 20 - 30%]]> Sun, 05 Sep 2010 00:09:00 http://www.novonordisk-jobs.com/job/PRINCETON-Director,-Clinical-Research-Inflammation-Job-NJ-08540/698950/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS http://www.novonordisk-jobs.com/job/PRINCETON-Director,-Clinical-Research-Inflammation-Job-NJ-08540/698950/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W%5FRSS